- yuki:
您好:那如果您有買到D... - yuki:
您好:請問您有買到-&... - xanadu:
真開心!!9/11終於... - elvira:
你好,打從網路搜尋路過... - andrew:
好萊塢2008即將上映...
累積人次:
荒木飛呂彥的插畫, 難道Cell成了連載漫畫?
愛知縣岡崎市自然科學研究機構生理学研究所的瀬藤光
封面主角這個替身叫 "SCRAPPER", 是一種新發現的E3泛素連接酶(ubiquitin ligase), 負責調節突觸泡體(synaptic vesicle)的釋放, 可將RIM1蛋白(一種小的G protein Rab3-interacting molecule)泛激素化(ubiquitinate), 而使之降解, 在SCRAPPER剔除小鼠的神經元會有亢奮電生理學的活性, 並且增加RIM1的數量, 這些現象可藉由重新表現 SCRAPPER 或是剔除RIM1來補救, 結果顯示蛋白質降解對突觸神經活性的重要性。圖呈現紫色的SCRAPPER把藍色心型的ubiquitins 放到紅色的RIM。完整研究在該期943-957頁。
封面說明原文如下: Presynaptic plasticity is a fundamental, yet poorly understood, neural phenomenon that is thought to be the basis of learning and memory. In this issue, Yao et al. (pp. 943–957) identify a novel ubiquitin ligase named SCRAPPER, which is responsible for tuning of synaptic vesicle release probability. SCRAPPER ubiquitinates presynaptic active zone protein RIM1, triggering its proteasomal degradation. Neurons from the Scrapper-knockout mice have hyper electrophysiological activity and contained increased amount of RIM1, and these phenotypes could be rescued by re-expression of SCRAPPER or knockdown of RIM1. The results highlight the importance of protein degradation in the regulation of synaptic activity in vivo. On the cover, the purple SCRAPPER humanoid is putting blue heart-shaped ubiquitins on the red RIM creatures. Japanese manga artist Hirohiko Araki created the cover image with scientific direction from Drs. Setou and Ageta.
另附摘要於後:
Little is known about how synaptic activity is modulated in the central nervous system. We have identified SCRAPPER, a synapse-localized E3 ubiquitin ligase, which regulates neural transmission. SCRAPPER directly binds and ubiquitinates RIM1, a modulator of presynaptic plasticity. In neurons from Scrapper-knockout (SCR-KO) mice, RIM1 had a longer half-life with significant reduction in ubiquitination, indicating that SCRAPPER is the predominant ubiquitin ligase that mediates RIM1 degradation. As anticipated in a RIM1 degradation defect mutant, SCR-KO mice displayed altered electrophysiological synaptic activity, i.e., increased frequency of miniature excitatory postsynaptic currents. This phenotype of SCR-KO mice was phenocopied by RIM1 overexpression and could be rescued by re-expression of SCRAPPER or knockdown of RIM1. The acute effects of proteasome inhibitors, such as upregulation of RIM1 and the release probability, were blocked by the impairment of SCRAPPER. Thus, SCRAPPER has an essential function in regulating proteasome-mediated degradation of RIM1 required for synaptic tuning.
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隔日早上,她的車子在距離她家僅半英里的Newlands Corner一處斜坡底下被發現,車裡沒有人。車子的前輪懸空在一個120英尺的懸崖的邊上。剎車失控,變速桿掛在空檔,引擎開著。車裡留著一些衣服,包括一件皮大衣。
接著在星期一,警察公布她的失蹤,馬上登上報紙的頭條。上百個警察和成千個志願者搜索了附近的村子。潛水員也搜索了Silent Pool(附近的一個號稱深不見底的湖)。
最合理的解釋就是這位著名女作家出事了! 
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39歲對許多人來說真是一個難以熬過的年紀,岳飛、馬丁·路德·金恩、蕭邦...等人皆是如此... “關於"Che"這個字,Guevara本名為Ernesto Guevara Serna,有資料說" Che "原本是阿根廷人相互之間的親切稱呼,與我們說的"哥們兒"類似。因為Guevara是阿根廷人,同伴們都戲稱他"Che",久而久之,就成了他姓名的一部分。另外,另外也有資料說,Guevara在1959年受封為古巴榮譽公民時,正式接受"Che"這個"暱稱"(大美百科全書)
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癌症,聽起來好像只是一種疾病,卻可以發生在人體每個部位,症狀千變萬化,令人難以捉摸。長久以來,癌症的起源始終成謎,科學家絞盡腦汁,只為揪出癌症的病因。
一直到二十世紀後半,拜分子生物學所賜,操縱癌細胞形成的力量一一現形。原來,癌症來自我們自己,源頭就是深藏於身體細胞中,帶著生命所有密碼的基因。一個原本在體內執行正常任務的基因,發生微細的變化,攪亂了細胞正常的運作狀態。這個細胞再也不聽命於生長控制機制,背叛了身體這個群體,開始有自己的意志,不停地分裂生長,最後發展成致命腫瘤。
~~~~~~~~~摘自One Renegade Cell內容大綱
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